Phytocompounds from Withania somnifera against breast cancer: An in-silico study

نویسندگان

چکیده

Introduction and Aim: Withania somnifera, called as Indian Ginseng is a very important plant in traditional medicinal practices. The possesses wide range of activity has been used to treat multiple diseases. anti-inflammatory, neuroprotective, hypoglycemic, antiarthritic, hepatoprotective, antioxidant, anti-stress, immunostimulatory anti-cancer therapeutic activities. Cancer health burden prevalent worldwide and, breast cancer the top major cause death among women people low middle-income countries are affected higher number because they have treatment access. This an in-silico study focused on studying interaction between five phytocompounds namely, anaferine, isopelletierin, sitoindoside IX, somniferine, withanone present W.somnifera 3 proteins involved pathway viz., C-Raf, AKt 2 GSK 3? through molecular docking. Methodology: We retrieved above three from PDB, ligands PubChem, docking was done. Docking against target were carried out using Auto dock vina. Results: From results, we found that phytocompounds; somnifera effective inhibiting causing whereas anaferine isopelletierin less cancer. Conclusion: concludes W. potential ability These findings will aid development natural based therapy

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ژورنال

عنوان ژورنال: Biomedicine

سال: 2022

ISSN: ['2211-8020', '2211-8039']

DOI: https://doi.org/10.51248/.v42i4.1244